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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50280535
Substrate
n/a
Meas. Tech.
ChEMBL_139647 (CHEMBL872655)
Ki
1250±n/a nM
Citation
 Shapiro, G; Floersheim, P; Amstutz, R; Boddeke, H; Bolliger, G; Cottens, S; Enz, A; Gmelin, G; Gull, P; Supavilai, P Muscarinic agonist SAR of azaspirodioxolanes Bioorg Med Chem Lett 2:815-820 (1992)    Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50280535
Synonyms:
(2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane] | 2'-methyl-(2'R)-spiro[4-azabicyclo[2.2.2]octane-2,5'-(dihydro[1,3]oxathiolane)] | CHEMBL167593
Type:
Small organic molecule
Emp. Form.:
C10H17NOS
Mol. Mass.:
199.313
SMILES:
C[C@@H]1OC2(CS1)CN1CCC2CC1 |wU:1.0,TLB:4:3:11.12:9.8,THB:2:3:11.12:9.8,(.21,-.57,;1.01,-1.91,;.38,-3.34,;1.55,-4.38,;2.87,-3.58,;2.54,-2.07,;.71,-5.22,;.71,-6.59,;2.3,-7.55,;3.1,-6.4,;1.55,-5.48,;-.16,-6.25,;-.96,-7.48,)|
Structure:
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