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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50280558
Substrate
n/a
Meas. Tech.
ChEMBL_139647 (CHEMBL872655)
Ki
765±n/a nM
Citation
 Shapiro, G; Floersheim, P; Amstutz, R; Boddeke, H; Bolliger, G; Cottens, S; Enz, A; Gmelin, G; Gull, P; Supavilai, P Muscarinic agonist SAR of azaspirodioxolanes Bioorg Med Chem Lett 2:815-820 (1992)    Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50280558
Synonyms:
2-Ethyl-8-methyl-8-aza-spiro[4.5]decane-1,3-dione | CHEMBL433912
Type:
Small organic molecule
Emp. Form.:
C12H19NO2
Mol. Mass.:
209.2848
SMILES:
CCC1C(=O)CC2(CCN(C)CC2)C1=O
Structure:
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