Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50449645
Substrate
n/a
Meas. Tech.
ChEBML_139646
Ki
105±n/a nM
Citation
 Shapiro, G; Floersheim, P; Amstutz, R; Boddeke, H; Bolliger, G; Cottens, S; Enz, A; Gmelin, G; Gull, P; Supavilai, P Muscarinic agonist SAR of azaspirodioxolanes Bioorg Med Chem Lett 2:815-820 (1992)    Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50449645
Synonyms:
AF-102B | CHEMBL2021361 | FKS-508 | SND-5008 | SNI-2011 | SNK-508
Type:
Small organic molecule
Emp. Form.:
C10H17NOS
Mol. Mass.:
199.313
SMILES:
C[C@H]1OC2(CS1)CN1CCC2CC1 |r,wD:1.0,(26.77,-12.75,;25.3,-13.54,;24.07,-12.62,;22.81,-13.51,;23.3,-15.01,;24.79,-15.01,;22.81,-11.93,;21.47,-11.16,;20.92,-12.45,;22.01,-13.12,;21.47,-14.28,;20.15,-13.51,;20.15,-11.98,)|
Structure:
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