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Target
S-adenosylmethionine decarboxylase proenzyme
Ligand
BDBM50403124
Substrate
n/a
Meas. Tech.
ChEMBL_196572 (CHEMBL800450)
Ki
3800±n/a nM
Citation
 Wu, YQ; Lawrence, T; Guo, JQ; Woster, PM -cyano-substituted analogoues of decarboxylated S-adenosylmethionine as enzyme activated, irreversible inhibitors of S-adenosylmethionine decarboxylase Bioorg Med Chem Lett 3:2811-2816 (1993)    Article 
Target
Name:
S-adenosylmethionine decarboxylase proenzyme
Synonyms:
AMD | AMD1 | DCAM_HUMAN | S-Adenosylmethionine Decarboxylase (AdoMetDC) | S-adenosylmethionine decarboxylase 1 | SAMDC
Type:
Heterotetramer of two alpha and two beta chains
Mol. Mass.:
38337.21
Organism:
Homo sapiens (Human)
Description:
For the production of protein for the hAdoMetDC enzyme assays, the plasmid containing (H)6 tag at the carboxyl end (replacing -QQQQQS) was used.
Residue:
334
Sequence:
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
  
Inhibitor
Name:
BDBM50403124
Synonyms:
CHEMBL2115571
Type:
Small organic molecule
Emp. Form.:
C15H23N6O5S
Mol. Mass.:
399.445
SMILES:
C[S+](CCC(N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
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