Reaction Details Report a problem with these data
Target
S-adenosylmethionine decarboxylase proenzyme
Ligand
BDBM50366316
Substrate
n/a
Meas. Tech.
ChEBML_197377
Ki
960000±n/a nM
Citation
 Guo, JQ; Wu, YQ; Farmer, WL; Douglas, KA; Woster, PM; Garofalo, J; Basshi, CJ Restricted rotation analogs of S-adenosylmethionine: synthesis, evaluation as inhibitors of S-adenosylmethionine decarboxylase, and potential use as selective antitrypanosomal agents Bioorg Med Chem Lett 3:147-152 (1993)    Article 
Target
Name:
S-adenosylmethionine decarboxylase proenzyme
Synonyms:
AMD | AMD1 | DCAM_HUMAN | S-Adenosylmethionine Decarboxylase (AdoMetDC) | S-adenosylmethionine decarboxylase 1 | SAMDC
Type:
Heterotetramer of two alpha and two beta chains
Mol. Mass.:
38337.21
Organism:
Homo sapiens (Human)
Description:
For the production of protein for the hAdoMetDC enzyme assays, the plasmid containing (H)6 tag at the carboxyl end (replacing -QQQQQS) was used.
Residue:
334
Sequence:
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
  
Inhibitor
Name:
BDBM50366316
Synonyms:
CHEMBL3392209 | CHEMBL605267
Type:
Small organic molecule
Emp. Form.:
C15H22N6O9S2
Mol. Mass.:
494.5
SMILES:
OS(O)(=O)=O.Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CS[C@H]2CN[C@@H](C2)C(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: