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Target
Aminopeptidase B
Ligand
BDBM50282726
Substrate
n/a
Meas. Tech.
ChEMBL_35336 (CHEMBL645443)
IC50
28000±n/a nM
Citation
 Luisa Sua rez-Gea, M; Garci a-Lo pez, T; Pe rez, C; Herranz, R Pseudopeptide inhibitors of aminopeptidases containing the [CH(CN)NH] surrogate as a transition-state MIMIC Bioorg Med Chem Lett 4:1491-1496 (1994)    Article 
Target
Name:
Aminopeptidase B
Synonyms:
AMPB_MOUSE | AP-B | Arginine aminopeptidase | Arginyl aminopeptidase | Cytosol aminopeptidase IV | Rnpep
Type:
PROTEIN
Mol. Mass.:
72401.87
Organism:
Mus musculus
Description:
ChEMBL_35337
Residue:
650
Sequence:
MESGGPGNYSAAARRPLHSAQAVDVASASSFRAFEILHLHLDLRAEFGPPGPGPGSRGLSGTATLELRCLLPEGASELRLDSHSCLEVTAATLRRGQPGDQQAPAEPVPFHTQPFSHYGQALCVAFRQPCGAADRFELELTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALIEVPDGFTAVMSADTWEKRGPNKFFFQMSHPIPSYLIALAIGDLASAEVGPRSRVWAEPCLIEAAKEEYSGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMNVSGEENPLNKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGDQDQFDKFLKAYVDEFKFQSILAEDFLEFYLEYFPELKKKGVDSIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAELWVTSEPDMQAIEAVAISTWKTYQLVYFLDKILQKSPLPPGNVKKLGETYPKISNAQNAELRLRWGQIILKNDYQEEFQKVKDFLQSQGKQKYTLPLYHAMMGGSEMARTLAKDTFAATASQLHSNVVNYVQQILAPKDS
  
Inhibitor
Name:
BDBM50282726
Synonyms:
(S)-1-[(S)-2-((1R,2S)-2-Amino-1-cyano-3-phenyl-propylamino)-4-methyl-1-oxo-pentyl]-pyrrolidine-2-carboxylic acid methyl ester | CHEMBL35092
Type:
Small organic molecule
Emp. Form.:
C22H32N4O3
Mol. Mass.:
400.5145
SMILES:
COC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)N[C@@H](C#N)[C@@H](N)Cc1ccccc1
Structure:
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