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Target
Neuromedin-K receptor
Ligand
BDBM50282782
Substrate
n/a
Meas. Tech.
ChEBML_142869
IC50
22±n/a nM
Citation
 Boden, P; Eden, J; Hodgson, J; Horwell, D; Howson, W; Hughes, J; McKnight, A; Meecham, K; Pritchard, M; Raphy, J; Ratcliffe, G; Suman-Chauhan, N; Woodruff, G The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design Bioorg Med Chem Lett 4:1679-1684 (1994)    Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK3R_CAVPO | Neurokinin 3 receptor | Neurokinin NK3 | Neuromedin-K receptor | TACR3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49456.44
Organism:
GUINEA PIG
Description:
Neurokinin NK3 TACR3 GUINEA PIG::P30098
Residue:
440
Sequence:
MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIYALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDELELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSKSTSTTASFVSSSHMSVEEGS
  
Inhibitor
Name:
BDBM50282782
Synonyms:
CHEMBL297327 | {(S)-1-[(R)-1-(8-Hydroxy-octylcarbamoyl)-2-phenyl-ethylcarbamoyl]-1-methyl-2-phenyl-ethyl}-carbamic acid tert-butyl ester
Type:
Small organic molecule
Emp. Form.:
C32H47N3O5
Mol. Mass.:
553.7327
SMILES:
CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO
Structure:
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