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Target
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Ligand
BDBM50289212
Substrate
n/a
Meas. Tech.
ChEBML_161425
IC50
40000±n/a nM
Citation
 McCluskey, A; Taylor, C; Quinn, RJ; Suganuma, M; Fujiki, H Inhibition of protein phosphatase 2A by cantharidin analogues Bioorg Med Chem Lett 6:1025-1028 (1996)    Article 
Target
Name:
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Synonyms:
2AAA_MOUSE | Ppp2r1a | Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
Type:
PROTEIN
Mol. Mass.:
65303.23
Organism:
Mus musculus
Description:
ChEMBL_161425
Residue:
589
Sequence:
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMTQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
  
Inhibitor
Name:
BDBM50289212
Synonyms:
4,10-Dioxa-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione | CHEMBL273883
Type:
Small organic molecule
Emp. Form.:
C8H6O4
Mol. Mass.:
166.1308
SMILES:
O=C1OC(=O)C2C3OC(C=C3)C12 |c:9,TLB:1:11:7:9.10,3:5:7:9.10|
Structure:
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