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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50291593
Substrate
n/a
Meas. Tech.
ChEBML_140112
Ki
>10000±n/a nM
Citation
 Hudkins, RL; DeHaven-Hudkins, DL; Doukas, P Design of dual acting anticonvulsant-antimuscarinic succinimide and hydantoin derivatives Bioorg Med Chem Lett 7:979-984 (1997)    Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50291593
Synonyms:
1'-(4-tetrahydro-1H-1-pyrrolyl-2-butynyl)spiro[2,3-dihydro-1H-indene-1,3'-(tetrahydro-1'H-pyrrole)]-2',5'-dione | CHEMBL177259
Type:
Small organic molecule
Emp. Form.:
C20H22N2O2
Mol. Mass.:
322.4009
SMILES:
O=C1CC2(CCc3ccccc23)C(=O)N1CC#CCN1CCCC1
Structure:
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