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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50057501
Substrate
n/a
Meas. Tech.
ChEMBL_204898 (CHEMBL808567)
Ki
1200±n/a nM
Citation
 Guarna, A; Occhiato, EG; Scarpi, D; Tsai, R; Danza, G; Comerci, A; Mancina, R; Serio, M Synthesis of benzo[c]quinolizin-3-ones: selective non-steroidal inhibitors of steroid 5 alpha-reductase 1. Bioorg Med Chem Lett 8:2871-6 (1999) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50057501
Synonyms:
(S)-7-Chloro-4a-methyl-3,4,4a,9-tetrahydro-phenanthrene-2-carboxylic acid | CHEMBL25081
Type:
Small organic molecule
Emp. Form.:
C16H15ClO2
Mol. Mass.:
274.742
SMILES:
C[C@]12CCC(=CC1=CCc1cc(Cl)ccc21)C(O)=O |c:4,7|
Structure:
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