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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50057501
Substrate
n/a
Meas. Tech.
ChEBML_204905
Ki
260±n/a nM
Citation
 Guarna, A; Occhiato, EG; Scarpi, D; Tsai, R; Danza, G; Comerci, A; Mancina, R; Serio, M Synthesis of benzo[c]quinolizin-3-ones: selective non-steroidal inhibitors of steroid 5 alpha-reductase 1. Bioorg Med Chem Lett 8:2871-6 (1999) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50057501
Synonyms:
(S)-7-Chloro-4a-methyl-3,4,4a,9-tetrahydro-phenanthrene-2-carboxylic acid | CHEMBL25081
Type:
Small organic molecule
Emp. Form.:
C16H15ClO2
Mol. Mass.:
274.742
SMILES:
C[C@]12CCC(=CC1=CCc1cc(Cl)ccc21)C(O)=O |c:4,7|
Structure:
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