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Target
GTPase HRas
Ligand
BDBM50072339
Substrate
n/a
Meas. Tech.
ChEBML_82665
IC50
8000±n/a nM
Citation
 Baraldi, PG; Cacciari, B; Guiotto, A; Leoni, A; Romagnoli, R; Spalluto, G; Mongelli, N; Howard, PW; Thurston, DE; Bianchi, N; Gambari, R Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid. Bioorg Med Chem Lett 8:3019-24 (1999) [PubMed]  Article 
Target
Name:
GTPase HRas
Synonyms:
GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:
Other Protein Type
Mol. Mass.:
21293.37
Organism:
Homo sapiens (Human)
Description:
P01112
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
  
Inhibitor
Name:
BDBM50072339
Synonyms:
Benzodiazepine-Distamycin Hybrid | CHEMBL102341
Type:
Small organic molecule
Emp. Form.:
C37H43N11O7
Mol. Mass.:
753.8068
SMILES:
COc1cc2c(cc1OCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCC(N)=N)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1CCCN1C2=O |c:50|
Structure:
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