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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50076050
Substrate
n/a
Meas. Tech.
ChEBML_61361
IC50
1.2±n/a nM
Citation
 Meltzer, PC; Blundell, P; Chen, Z; Yong, YF; Madras, BK Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters. Bioorg Med Chem Lett 9:857-62 (1999) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DAT1 | Dopamine transporter | SC6A3_MACFA | SLC6A3
Type:
PROTEIN
Mol. Mass.:
68455.12
Organism:
Macaca fascicularis
Description:
ChEMBL_61362
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAMGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHSGDSGGNGPGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50076050
Synonyms:
3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester | CHEMBL88915
Type:
Small organic molecule
Emp. Form.:
C16H17Cl2NO2
Mol. Mass.:
326.218
SMILES:
COC(=O)C1=C(CC2CCC1N2C)c1ccc(Cl)c(Cl)c1 |t:4,THB:12:11:4.5.6:9.8,13:5:11:9.8,2:4:11:9.8|
Structure:
Search PDB for entries with ligand similarity: