Reaction Details Report a problem with these data
Target
Threonine--tRNA ligase 1, cytoplasmic
Ligand
BDBM50366646
Substrate
n/a
Meas. Tech.
ChEBML_210571
IC50
15±n/a nM
Citation
 Forrest, AK; Jarvest, RL; Mensah, LM; O'Hanlon, PJ; Pope, AJ; Sheppard, RJ Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases. Bioorg Med Chem Lett 10:1871-4 (2000) [PubMed]  Article 
Target
Name:
Threonine--tRNA ligase 1, cytoplasmic
Synonyms:
SYTC_HUMAN | TARS | TARS1 | Threonyl-tRNA synthetase
Type:
PROTEIN
Mol. Mass.:
83435.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_935846
Residue:
723
Sequence:
MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEMYNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIAKVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGISFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEF
  
Inhibitor
Name:
BDBM50366646
Synonyms:
CHEMBL1163068
Type:
Small organic molecule
Emp. Form.:
C14H21N7O8S
Mol. Mass.:
447.424
SMILES:
C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity: