Reaction Details Report a problem with these data
Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM50085413
Substrate
n/a
Meas. Tech.
ChEBML_217655
IC50
32±n/a nM
Citation
 Lackey, K; Cory, M; Davis, R; Frye, SV; Harris, PA; Hunter, RN; Jung, DK; McDonald, OB; McNutt, RW; Peel, MR; Rutkowske, RD; Veal, JM; Wood, ER The discovery of potent cRaf1 kinase inhibitors. Bioorg Med Chem Lett 10:223-6 (2000) [PubMed]  Article 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM50085413
Synonyms:
3-(3,5-dichloro-4-hydroxybenzylidene)-5-phenylindolin-2-one | 3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-phenyl-1,3-dihydro-indol-2-one | CHEMBL73470
Type:
Small organic molecule
Emp. Form.:
C21H13Cl2NO2
Mol. Mass.:
382.239
SMILES:
Oc1c(Cl)cc(\C=C2/C(=O)Nc3ccc(cc23)-c2ccccc2)cc1Cl
Structure:
Search PDB for entries with ligand similarity: