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Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM50085414
Substrate
n/a
Meas. Tech.
ChEBML_217655
IC50
13±n/a nM
Citation
 Lackey, K; Cory, M; Davis, R; Frye, SV; Harris, PA; Hunter, RN; Jung, DK; McDonald, OB; McNutt, RW; Peel, MR; Rutkowske, RD; Veal, JM; Wood, ER The discovery of potent cRaf1 kinase inhibitors. Bioorg Med Chem Lett 10:223-6 (2000) [PubMed]  Article 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM50085414
Synonyms:
3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid methyl ester | CHEMBL424048
Type:
Small organic molecule
Emp. Form.:
C17H11Br2NO4
Mol. Mass.:
453.082
SMILES:
COC(=O)c1ccc2NC(=O)\C(=C/c3cc(Br)c(O)c(Br)c3)c2c1
Structure:
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