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Target
Nitric oxide synthase, inducible
Ligand
BDBM50230993
Substrate
n/a
Meas. Tech.
ChEBML_89185
IC50
6600±n/a nM
Citation
 Young, RJ; Beams, RM; Carter, K; Clark, HA; Coe, DM; Chambers, CL; Davies, PI; Dawson, J; Drysdale, MJ; Franzman, KW; French, C; Hodgson, ST; Hodson, HF; Kleanthous, S; Rider, P; Sanders, D; Sawyer, DA; Scott, KJ; Shearer, BG; Stocker, R; Smith, S; Tackley, MC; Knowles, RG Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. Bioorg Med Chem Lett 10:597-600 (2000) [PubMed]  Article 
Target
Name:
Nitric oxide synthase, inducible
Synonyms:
HEP-NOS | Hepatocyte NOS | Inducible NO synthase | Inducible NOS | NOS type II | NOS2 | NOS2A | NOS2_HUMAN | Nitric oxide synthase, inducible (iNOS) | iNOS
Type:
Homodimer
Mol. Mass.:
131141.95
Organism:
Homo sapiens (Human)
Description:
P35228
Residue:
1153
Sequence:
MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDRVAVQPSSLEMSAL
  
Inhibitor
Name:
BDBM50230993
Synonyms:
(2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid | (2S)-2-ammonio-5-{[iminio(methylamino)methyl]amino}pentanoate | (R)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | (S)-2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | (S)-2-amino-5-(2-methylguanidino)pentanoic acid | (S)-2-amino-5-(3-methylguanidino)pentanoic acid | 2-Amino-5-(N'-methyl-guanidino)-pentanoic acid | CHEMBL256147 | L-NMMA | N omega-methyl-L-arginine | N(G)-mono-methyl-L-arginine | N(G)-monomethyl-L-arginine | N-Monomethyl-L-arginine | N-gamma-monomethyl-L-arginine | NG-Monomethyl-L-Arginine | NG-monomethyl-L-arginine acetate | Ngamma-monomethyl-L-arginine | Targinine
Type:
Small organic molecule
Emp. Form.:
C7H16N4O2
Mol. Mass.:
188.2275
SMILES:
CNC(N)=NCCC[C@H](N)C(O)=O |r,w:4.4|
Structure:
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