Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM50102211
Substrate
n/a
Meas. Tech.
ChEBML_208175
Ki
3950±n/a nM
Citation
 Kokko, KP; Arrigoni, CE; Dix, TA Selectivity enhancement induced by substitution of non-natural analogues of arginine and lysine in arginine-based thrombin inhibitors. Bioorg Med Chem Lett 11:1947-50 (2001) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50102211
Synonyms:
5-Dimethylamino-naphthalene-1-sulfonic acid [4-(4,5-dihydro-1H-imidazol-2-ylamino)-1-(piperidine-1-carbonyl)-butyl]-amide; hydrochloride | CHEMBL558029
Type:
Small organic molecule
Emp. Form.:
C25H36N6O3S
Mol. Mass.:
500.657
SMILES:
CN(C)c1cccc2c(cccc12)S(=O)(=O)NC(CCCNC1=NCCN1)C(=O)N1CCCCC1 |t:24|
Structure:
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