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Target
Plasminogen activator inhibitor 1
Ligand
BDBM50104503
Substrate
n/a
Meas. Tech.
ChEBML_155616
IC50
3100±n/a nM
Citation
 Folkes, A; Roe, MB; Sohal, S; Golec, J; Faint, R; Brooks, T; Charlton, P Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett 11:2589-92 (2001) [PubMed]  Article 
Target
Name:
Plasminogen activator inhibitor 1
Synonyms:
Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:
Enzyme
Mol. Mass.:
45064.00
Organism:
Homo sapiens (Human)
Description:
P05121
Residue:
402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
  
Inhibitor
Name:
BDBM50104503
Synonyms:
CHEMBL87927 | Thiophene-2-carboxylic acid {4-[5-[1-[5-(2-dimethylamino-ethylsulfanyl)-thiophen-2-yl]-meth-(Z)-ylidene]-3,6-dioxo-piperazin-(2Z)-ylidenemethyl]-phenyl}-amide
Type:
Small organic molecule
Emp. Form.:
C25H24N4O3S3
Mol. Mass.:
524.678
SMILES:
CN(C)CCSc1ccc(\C=c2/[nH]c(=O)\c(=C\c3ccc(NC(=O)c4cccs4)cc3)[nH]c2=O)s1
Structure:
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