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Target
Histone deacetylase
Ligand
BDBM50218957
Substrate
n/a
Meas. Tech.
ChEMBL_79057 (CHEMBL692692)
IC50
10±n/a nM
Citation
 Colletti, SL; Myers, RW; Darkin-Rattray, SJ; Gurnett, AM; Dulski, PM; Galuska, S; Allocco, JJ; Ayer, MB; Li, C; Lim, J; Crumley, TM; Cannova, C; Schmatz, DM; Wyvratt, MJ; Fisher, MH; Meinke, PT Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2. Bioorg Med Chem Lett 11:113-7 (2001) [PubMed]  Article 
Target
Name:
Histone deacetylase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
50433.01
Organism:
Cryptosporidium parvum
Description:
ChEMBL_79057
Residue:
444
Sequence:
MAKRVSYFYDGDIGSYYYGPGHPMKPQRIRMAHNLILSYDLYKHMEIYKPHKSPQSELVYFHEEDYINFLSSINPDNSKDFGLQLKRFNLGETTDCPVFDGLFEFQQICAGGSIDGAYKLNNEQSDICINWSGGLHHAKRSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYLSHRVLTVSFHKFGEFFPGTGDITDIGVAQGKYYSVNVPLNDGIDDDSFLSLFKPIISKCIEVYRPGAIVLQCGADSVRGDRLGRFNLSIKGHAECVEFCKKFNIPLLILGGGGYTIRNVARTWAYETATILDRTDLISDNIPLNDYYDYFAPDFKLHIPPLNLPNMNSPEHLEKIKAKVIDNLRYLEHAPGVEFAYVPSDFFDREASNLQKQEDEEREEELSSWQGGGRAAGSTESQGNHNEKPKSSRKLQKEHASEFY
  
Inhibitor
Name:
BDBM50218957
Synonyms:
CHEMBL1793967
Type:
Small organic molecule
Emp. Form.:
C33H45N5O6
Mol. Mass.:
607.7403
SMILES:
[H][C@](C)(CC)[C@]1([H])NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCCCC(=O)CC)NC(=O)[C@@]2([H])CCCCN2C1=O)C(=O)c1c[nH]c2ccccc12
Structure:
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