Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Lck
Ligand
BDBM50112973
Substrate
n/a
Meas. Tech.
ChEBML_221513
IC50
1100±n/a nM
Citation
 Hobbs, CJ; Bit, RA; Cansfield, AD; Harris, B; Hill, CH; Hilyard, KL; Kilford, IR; Kitas, E; Kroehn, A; Lovell, P; Pole, D; Rugman, P; Sherborne, BS; Smith, IE; Vesey, DR; Walmsley, DL; Whittaker, D; Williams, G; Wilson, F; Banner, D; Surgenor, A; Borkakoti, N Structure-based design of peptidomimetic antagonists of p56(lck) SH2 domain. Bioorg Med Chem Lett 12:1365-9 (2002) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50112973
Synonyms:
CHEMBL418579 | Phosphoric acid mono-[4-((S)-2-acetylamino-2-{(4S,7S)-4-[(adamantan-1-ylmethyl)-carbamoyl]-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamoyl}-ethyl)-phenyl] ester
Type:
Small organic molecule
Emp. Form.:
C32H44N5O9P
Mol. Mass.:
673.6936
SMILES:
CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@H]1CCC(=O)N2CCC[C@H](N2C1=O)C(=O)NCC12CC3CC(CC(C3)C1)C2 |TLB:40:41:45:39.38.44,THB:42:41:38:43.45.44,42:43:38:41.46.40,40:39:45:41.46.42|
Structure:
Search PDB for entries with ligand similarity: