Reaction Details Report a problem with these data
Target
Adenosylhomocysteinase
Ligand
BDBM50366809
Substrate
n/a
Meas. Tech.
ChEBML_196550
Ki
67000±n/a nM
Citation
 Guillerm, G; Guillerm, D; Vandenplas-Vitkowski, C; Glapski, C; De Clercq, E Inactivation of S-adenosyl-L-homocysteine hydrolase with novel 5'-thioadenosine derivatives. Antiviral effects. Bioorg Med Chem Lett 13:1649-52 (2003) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50366809
Synonyms:
CHEMBL604826
Type:
Small organic molecule
Emp. Form.:
C11H12N6O3S
Mol. Mass.:
308.316
SMILES:
Nc1ncnc2n(cnc12)C1O[C@H](CSC#N)[C@@H](O)[C@H]1O |r|
Structure:
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