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Target
Thymidylate kinase
Ligand
BDBM50132289
Substrate
n/a
Meas. Tech.
ChEBML_208218
Ki
490000±n/a nM
Citation
 Vanheusden, V; Van Rompaey, P; Munier-Lehmann, H; Pochet, S; Herdewijn, P; Van Calenbergh, S Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Bioorg Med Chem Lett 13:3045-8 (2003) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk
Type:
PROTEIN
Mol. Mass.:
22636.29
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_208218
Residue:
214
Sequence:
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
  
Inhibitor
Name:
BDBM50132289
Synonyms:
1-((2R,5S)-4-Azido-3-hydroxy-5-iodomethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | CHEMBL102479
Type:
Small organic molecule
Emp. Form.:
C10H12IN5O4
Mol. Mass.:
393.1379
SMILES:
Cc1cn([C@@H]2O[C@H](CI)[C@@H](N=[N+]=[N-])[C@H]2O)c(=O)[nH]c1=O
Structure:
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