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Target
Melanocortin receptor 4
Ligand
BDBM50136518
Substrate
n/a
Meas. Tech.
ChEMBL_106183 (CHEMBL714602)
EC50
405±n/a nM
Citation
 Ujjainwalla, F; Warner, D; Walsh, TF; Wyvratt, MJ; Zhou, C; Yang, L; Kalyani, RN; MacNeil, T; Van der Ploeg, LH; Rosenblum, CI; Tang, R; Vongs, A; Weinberg, DH; Goulet, MT Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype. Bioorg Med Chem Lett 13:4431-5 (2003) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50136518
Synonyms:
(3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide; hydrochloride | CHEMBL137452 | CHEMBL541866
Type:
Small organic molecule
Emp. Form.:
C32H33ClN4O3S
Mol. Mass.:
589.147
SMILES:
COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNC[C@@H]2c2ccccc2)c1=O
Structure:
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