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Target
Histone deacetylase 8
Ligand
BDBM50366966
Substrate
n/a
Meas. Tech.
ChEBML_88030
IC50
34±n/a nM
Citation
 Nishino, N; Yoshikawa, D; Watanabe, LA; Kato, T; Jose, B; Komatsu, Y; Sumida, Y; Yoshida, M Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand. Bioorg Med Chem Lett 14:2427-31 (2004) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HDAC8_MOUSE | Hdac8 | Histone deacetylase
Type:
PROTEIN
Mol. Mass.:
41767.71
Organism:
Mus musculus
Description:
ChEMBL_88030
Residue:
377
Sequence:
MEMPEEPANSGHSLPPVYIYSPEYVSICDSLVKVPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDEDHPDSIEYGLGYDCPATEGIFDYAAAIGGGTITAAQCLIDGKCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFDRILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDMSDVGLGKGRYYSVNVPIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYVLQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50366966
Synonyms:
CHEMBL1790596
Type:
Small organic molecule
Emp. Form.:
C29H43N5O7
Mol. Mass.:
573.681
SMILES:
CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](CCCCCN(O)C=O)NC(=O)[C@@H]2CCCN2C1=O
Structure:
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