Reaction Details Report a problem with these data
Target
S-adenosylmethionine decarboxylase proenzyme
Ligand
BDBM50366974
Substrate
n/a
Meas. Tech.
ChEBML_197193
Ki
110000±n/a nM
Citation
 Pankaskie, M; Abdel-Monem, MM Inhibitors of polyamine biosynthesis. 8. Irreversible inhibition of mammalian S-adenosyl-L-methionine decarboxylase by substrate analogues. J Med Chem 23:121-7 (1980) [PubMed]  Article 
Target
Name:
S-adenosylmethionine decarboxylase proenzyme
Synonyms:
Amd1 | DCAM_RAT | S-adenosylmethionine decarboxylase 1
Type:
PROTEIN
Mol. Mass.:
38134.93
Organism:
Rattus norvegicus
Description:
ChEMBL_197052
Residue:
333
Sequence:
MEAAHFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDLPESRVINQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKIDGFKRLDCQSAMFNDYNFVFTSFAKKQQQQS
  
Inhibitor
Name:
BDBM50366974
Synonyms:
CHEMBL1204407 | CHEMBL3392141
Type:
Small organic molecule
Emp. Form.:
C14H25Cl2N7O3
Mol. Mass.:
410.299
SMILES:
Cl.Cl.CN(CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
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