Reaction Details Report a problem with these data
Target
Thymidine kinase, cytosolic
Ligand
BDBM50028581
Substrate
n/a
Meas. Tech.
ChEBML_123825
Ki
35000±n/a nM
Citation
 Hampton, A; Chawla, RR; Kappler, F Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes. J Med Chem 25:644-9 (1982) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_RAT | Thymidine kinase | Tk-1 | Tk1
Type:
PROTEIN
Mol. Mass.:
13514.16
Organism:
Rattus norvegicus
Description:
ChEMBL_208200
Residue:
121
Sequence:
MSYINLPTVLPISPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNSFSTHDRNTMDALPACMLKDVAQEALGVAVIGIDEGQFFPDIVDFCETMANTGKTVIV
  
Inhibitor
Name:
BDBM50028581
Synonyms:
1-(5-Hexylaminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | CHEMBL157402
Type:
Small organic molecule
Emp. Form.:
C16H27N3O4
Mol. Mass.:
325.4033
SMILES:
CCCCCCNCC1OC(CC1O)n1cc(C)c(=O)[nH]c1=O
Structure:
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