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Target
Thymidine kinase, cytosolic
Ligand
BDBM50205415
Substrate
n/a
Meas. Tech.
ChEMBL_200332 (CHEMBL804825)
Ki
6500±n/a nM
Citation
 Hampton, A; Hai, TT; Kappler, F; Chawla, RR Species- or isozyme-specific enzyme inhibitors. 6. Synthesis and evaluation of two-substrate condensation products as inhibitors of hexokinases and thymidine kinases. J Med Chem 25:801-5 (1982) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_RAT | Thymidine kinase | Tk-1 | Tk1
Type:
PROTEIN
Mol. Mass.:
13514.16
Organism:
Rattus norvegicus
Description:
ChEMBL_208200
Residue:
121
Sequence:
MSYINLPTVLPISPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNSFSTHDRNTMDALPACMLKDVAQEALGVAVIGIDEGQFFPDIVDFCETMANTGKTVIV
  
Inhibitor
Name:
BDBM50205415
Synonyms:
({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid | CHEMBL220940
Type:
Small organic molecule
Emp. Form.:
C10H17N2O15P3
Mol. Mass.:
498.1677
SMILES:
Cc1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O
Structure:
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