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Target
Mu-type opioid receptor
Ligand
BDBM50021198
Substrate
n/a
Meas. Tech.
ChEMBL_149014 (CHEMBL758578)
Ki
8160±n/a nM
Citation
 Schiller, PW; Nguyen, TM; Lemieux, C; Maziak, LA Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers. J Med Chem 28:1766-71 (1986) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50021198
Synonyms:
12-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-2-isobutyl-3,7,13-trioxo-1,4,8triaza-cyclotridecane-5-carboxylic acid amide | CHEMBL2372818
Type:
Small organic molecule
Emp. Form.:
C24H36N6O6
Mol. Mass.:
504.5792
SMILES:
CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(=O)C[C@H](NC1=O)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 |r|
Structure:
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