Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50022256
Substrate
n/a
Meas. Tech.
ChEBML_162176
IC50
77000±n/a nM
Citation
 Berry, DA; Gilbertsen, RB; Cook, PD Synthesis of 8-amino-3-deazaguanine via imidazole precursors. Antitumor activity and inhibition of purine nucleoside phosphorylase. J Med Chem 29:2034-7 (1986) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50022256
Synonyms:
6-Amino-1,5-dihydro-imidazo[4,5-c]pyridin-4-one | 6-Amino-3,5-dihydro-imidazo[4,5-c]pyridin-4-one | CHEMBL31882
Type:
Small organic molecule
Emp. Form.:
C6H6N4O
Mol. Mass.:
150.138
SMILES:
Nc1cc2nc[nH]c2c(=O)[nH]1
Structure:
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