Reaction Details Report a problem with these data
Target
Thymidine kinase
Ligand
BDBM50367744
Substrate
n/a
Meas. Tech.
ChEBML_207840
EC50
30000±n/a nM
Citation
 Focher, F; Hildebrand, C; Freese, S; Ciarrocchi, G; Noonan, T; Sangalli, S; Brown, N; Spadari, S; Wright, G N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase. J Med Chem 31:1496-500 (1988) [PubMed]  Article 
Target
Name:
Thymidine kinase
Synonyms:
KITH_HHV1S | TK | Thymidine kinase | UL23
Type:
PROTEIN
Mol. Mass.:
40883.42
Organism:
Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1)
Description:
ChEMBL_213
Residue:
376
Sequence:
MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMIQTHVTTPGSIPTICDLARTFAREMGEAN
  
Inhibitor
Name:
BDBM50367744
Synonyms:
CHEMBL603175
Type:
Small organic molecule
Emp. Form.:
C17H19N5O5
Mol. Mass.:
373.3633
SMILES:
Cc1ccc(Nc2nc3n(cnc3c(=O)[nH]2)C2O[C@@H](CO)[C@H](O)[C@@H]2O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: