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Target
D(1A) dopamine receptor
Ligand
BDBM50010580
Substrate
n/a
Meas. Tech.
ChEBML_58332
IC50
>50000±n/a nM
Citation
 Jaen, JC; Wise, LD; Caprathe, BW; Tecle, H; Bergmeier, S; Humblet, CC; Heffner, TG; Meltzer, LT; Pugsley, TA 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties. J Med Chem 33:311-7 (1990) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50010580
Synonyms:
4-(1-Allyl-1,2,5,6-tetrahydro-pyridin-3-yl)-thiazol-2-ylamine | CHEMBL106257
Type:
Small organic molecule
Emp. Form.:
C11H15N3S
Mol. Mass.:
221.322
SMILES:
Nc1nc(cs1)C1=CCCN(CC=C)C1 |t:7|
Structure:
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