Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50003525
Substrate
n/a
Meas. Tech.
ChEBML_154975
IC50
7.5±n/a nM
Citation
 Carceller, E; Almansa, C; Merlos, M; Giral, M; Bartrolí, J; García-Rafanell, J; Forn, J (Pyridylcyanomethyl)piperazines as orally active PAF antagonists. J Med Chem 35:4118-34 (1992) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50003525
Synonyms:
CHEMBL133742 | [4-(2,3-Diphenyl-acryloyl)-piperazin-1-yl]-pyridin-3-yl-acetonitrile; hydrate
Type:
Small organic molecule
Emp. Form.:
C26H24N4O
Mol. Mass.:
408.495
SMILES:
O=C(N1CCN(CC1)C(C#N)c1cccnc1)C(=C\c1ccccc1)\c1ccccc1
Structure:
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