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Target
Neutrophil elastase
Ligand
BDBM50005895
Substrate
n/a
Meas. Tech.
ChEBML_63648
IC50
1300±n/a nM
Citation
 Zembower, DE; Kam, CM; Powers, JC; Zalkow, LH Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G. J Med Chem 35:1597-605 (1992) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50005895
Synonyms:
CHEMBL416614 | Carbonic acid 4,5-bis-butoxycarbonyloxy-7-methyl-9,10-dioxo-9,10-dihydro-anthracen-2-yl ester butyl ester
Type:
Small organic molecule
Emp. Form.:
C30H34O11
Mol. Mass.:
570.5844
SMILES:
CCCCOC(=O)Oc1cc(OC(=O)OCCCC)c2C(=O)c3c(OC(=O)OCCCC)cc(C)cc3C(=O)c2c1
Structure:
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