Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50005885
Substrate
n/a
Meas. Tech.
ChEMBL_96627 (CHEMBL705700)
IC50
6000±n/a nM
Citation
 Zembower, DE; Kam, CM; Powers, JC; Zalkow, LH Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G. J Med Chem 35:1597-605 (1992) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50005885
Synonyms:
2-Hexyl-1-hydroxy-8-methoxy-anthraquinone | CHEMBL40805
Type:
Small organic molecule
Emp. Form.:
C21H22O4
Mol. Mass.:
338.397
SMILES:
CCCCCCc1ccc2C(=O)c3cccc(OC)c3C(=O)c2c1O
Structure:
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