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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50040287
Substrate
n/a
Meas. Tech.
ChEMBL_201715 (CHEMBL803752)
IC50
0.510000±n/a nM
Citation
 Wyrick, SD; Booth, RG; Myers, AM; Owens, CE; Kula, NS; Baldessarini, RJ; McPhail, AT; Mailman, RB Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity. J Med Chem 36:2542-51 (1993) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50040287
Synonyms:
(1R,3S)Dimethyl-(2-methyl-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine; hydrochloride | (1S, 3R) Dimethyl-(2-methyl-4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine; hydrochloride | CHEMBL542167 | Dimethyl-(4-phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine; hydrochloride
Type:
Small organic molecule
Emp. Form.:
C19H23N
Mol. Mass.:
265.3926
SMILES:
CN(C)[C@]1(C)C[C@@H](c2ccccc2)c2ccccc2C1
Structure:
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