Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50044033
Substrate
n/a
Meas. Tech.
ChEMBL_49581 (CHEMBL661234)
IC50
1.3±n/a nM
Citation
 Elliott, RL; Kopecka, H; Bennett, MJ; Shue, YK; Craig, R; Lin, CW; Bianchi, BR; Miller, TR; Witte, DG; Stashko, MA Tetrapeptide CCK agonists: structure-activity studies on modifications at the N-terminus. J Med Chem 37:309-13 (1994) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_CAVPO | Cholecystokinin A receptor | Cholecystokinin receptor type A | Cholecystokinin-1 receptor
Type:
n/a
Mol. Mass.:
48229.77
Organism:
Cavia porcellus
Description:
n/a
Residue:
430
Sequence:
MDVVDSLFVNGSNITSACELGFENETLFCLDRPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPSLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTGNMCRFLLPNDVMQQTWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFDAIQKKSAKERKTSTGSSGPMEDSDGCYLQKSRHPRKLELRQLSPSSSGSNRINRIRSSSSTANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAERHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGTPGVRGEMGEEEEGRTTGASLSRYSYSHMSTSAPPP
  
Inhibitor
Name:
BDBM50044033
Synonyms:
(S)-3-[(S)-2-((S)-2-Benzoylamino-3-1H-indol-3-yl-propionylamino)-6-(3-o-tolyl-ureido)-hexanoylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-N-methyl-succinamic acid | CHEMBL428103
Type:
Small organic molecule
Emp. Form.:
C46H52N8O8
Mol. Mass.:
844.9539
SMILES:
CN([C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCNC(=O)Nc1ccccc1C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1
Structure:
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