Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50033160
Substrate
n/a
Meas. Tech.
ChEMBL_138811 (CHEMBL747492)
IC50
56±n/a nM
Citation
 Ward, JS; Merritt, L; Calligaro, DO; Bymaster, FP; Shannon, HE; Sawyer, BD; Mitch, CH; Deeter, JB; Peters, SC; Sheardown, MJ Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles. J Med Chem 38:3469-81 (1995) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50033160
Synonyms:
3-(3-Chloro-pyrazin-2-yl)-1-aza-bicyclo[2.2.2]octane | CHEMBL327065
Type:
Small organic molecule
Emp. Form.:
C11H14ClN3
Mol. Mass.:
223.702
SMILES:
Clc1nccnc1C1CN2CCC1CC2 |(8.76,-3.74,;10.09,-4.51,;11.44,-3.76,;12.77,-4.53,;12.76,-6.07,;11.42,-6.82,;10.1,-6.05,;8.76,-6.82,;8.76,-8.36,;7.43,-9.12,;7.98,-7.58,;6.7,-7.47,;7.43,-6.04,;6.11,-6.82,;6.11,-8.36,)|
Structure:
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