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Target
Platelet-activating factor receptor
Ligand
BDBM50033223
Substrate
n/a
Meas. Tech.
ChEMBL_162884 (CHEMBL768980)
IC50
0.600000±n/a nM
Citation
 Fray, MJ; Cooper, K; Parry, MJ; Richardson, K; Steele, J Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine. J Med Chem 38:3514-23 (1995) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50033223
Synonyms:
7,8-Dimethyl-4-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepine-2-thione | CHEMBL434028
Type:
Small organic molecule
Emp. Form.:
C24H21N5S
Mol. Mass.:
411.522
SMILES:
Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(C)c(C)cc2NC(=S)C1 |t:19|
Structure:
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