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Target
Platelet-activating factor receptor
Ligand
BDBM50033254
Substrate
n/a
Meas. Tech.
ChEMBL_155148 (CHEMBL760189)
IC50
4±n/a nM
Citation
 Fray, MJ; Bull, DJ; Cooper, K; Parry, MJ; Stefaniak, MH Novel antagonists of platelet-activating factor. 2. Synthesis and structure-activity relationships of potent and long-acting heterofused [1,5]benzodiazepine and [1,4]diazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine. J Med Chem 38:3524-35 (1995) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50033254
Synonyms:
8-Bromo-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-3,5-dihydro-pyrido[3,4-b][1,4]diazepin-4-one | CHEMBL119452
Type:
Small organic molecule
Emp. Form.:
C21H15BrN6O
Mol. Mass.:
447.287
SMILES:
Cc1nc2cnccc2n1-c1ccc(cc1)C1=Nc2cc(Br)cnc2NC(=O)C1 |t:19|
Structure:
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