Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50254511
Substrate
n/a
Meas. Tech.
ChEMBL_145934 (CHEMBL748537)
IC50
2.6±n/a nM
Citation
 Davis, RD; Nelson, WL Isothiocyanate-substituted benzyl ether opioid receptor ligands derived from 6 beta-naltrexol. J Med Chem 38:570-9 (1995) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50254511
Synonyms:
CHEMBL468469 | Naltrexone-6-alpha-ol
Type:
Small organic molecule
Emp. Form.:
C20H25NO4
Mol. Mass.:
343.4168
SMILES:
O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CC1)c45 |r|
Structure:
Search PDB for entries with ligand similarity: