Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50051586
Substrate
n/a
Meas. Tech.
ChEMBL_70916 (CHEMBL684416)
IC50
2.30±n/a nM
Citation
 Azizeh, BY; Shenderovich, MD; Trivedi, D; Li, G; Sturm, NS; Hruby, VJ Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences. J Med Chem 39:2449-55 (1996) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GL-R | GLR_RAT | Gcgr
Type:
PROTEIN
Mol. Mass.:
55053.40
Organism:
Rattus norvegicus
Description:
ChEMBL_1450588
Residue:
485
Sequence:
MLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
  
Inhibitor
Name:
BDBM50051586
Synonyms:
CHEMBL413666 | [des-His1,Tyr5,Glu9,D-Tyr10]glucagon-NH2
Type:
Small organic molecule
Emp. Form.:
C153H223N41O47S
Mol. Mass.:
3420.719
SMILES:
n/a
Structure:
Search PDB for entries with ligand similarity: