Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM508
Substrate
n/a
Meas. Tech.
ChEMBL_90733 (CHEMBL701285)
IC50
37000±n/a nM
Citation
 Mazumder, A; Wang, S; Neamati, N; Nicklaus, M; Sunder, S; Chen, J; Milne, GW; Rice, WG; Burke, TR; Pommier, Y Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease. J Med Chem 39:2472-81 (1996) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM508
Synonyms:
2-[(2,4-dichlorophenyl)(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl]-3-hydroxy-1,4-dihydronaphthalene-1,4-dione | CHEMBL291663 | Cancer Chemotherapy National Service Center (CCNSC) compound 117272 | NSC 117272
Type:
Small organic molecule
Emp. Form.:
C27H14Cl2O6
Mol. Mass.:
505.302
SMILES:
Oc1c(O)c2ccccc2c(O)c1C(=C1C(=O)C(=O)c2ccccc2C1=O)c1ccc(Cl)cc1Cl |w:13.14|
Structure:
Search PDB for entries with ligand similarity: