Reaction Details Report a problem with these data
Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50050531
Substrate
n/a
Meas. Tech.
ChEMBL_207855 (CHEMBL810063)
Ki
1.2±n/a nM
Citation
 Rutledge, LD; Perlman, JH; Gershengorn, MC; Marshall, GR; Moeller, KD Conformationally restricted TRH analogs: a probe for the pyroglutamate region. J Med Chem 39:1571-4 (1996) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R | TRHR_MOUSE | Thyroliberin receptor | Trhr | thyrotropin-releasing hormone R1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44568.52
Organism:
MOUSE
Description:
thyrotropin-releasing hormone R1 TRHR MOUSE::P21761
Residue:
393
Sequence:
MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
  
Inhibitor
Name:
BDBM50050531
Synonyms:
1-[3-(1-methyl-4-imidazolyl)-2-[2-oxo-(5S)-dihydro-2H-5-pyrrolylcarboxamido]-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide | CHEMBL39363
Type:
Small organic molecule
Emp. Form.:
C17H24N6O4
Mol. Mass.:
376.4103
SMILES:
Cn1cnc(C[C@H](NC(=O)[C@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1
Structure:
Search PDB for entries with ligand similarity: