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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50059714
Substrate
n/a
Meas. Tech.
ChEMBL_3795 (CHEMBL619870)
IC50
100±n/a nM
Citation
 Hamel, P; Riendeau, D; Brideau, C; Chan, CC; Desmarais, S; Delorme, D; Dubé, D; Ducharme, Y; Ethier, D; Grimm, E; Falgueyret, JP; Guay, J; Jones, TR; Kwong, E; McAuliffe, M; McFarlane, CS; Piechuta, H; Roumi, M; Tagari, P; Young, RN; Girard, Y Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. J Med Chem 40:2866-75 (1997) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
5-LO | 5-Lipo-oxygenase (5-LOX) | 5-Lipoxygenase (5-LO) | 5-Lipoxygenase (LOX) | 5-Lipoygenase | 5-lipoxygenase/FLAP | ALOX5 | Arachidonate 5-lipoxygenase | LOG5 | LOX5_HUMAN
Type:
Enzyme
Mol. Mass.:
77972.74
Organism:
Homo sapiens (Human)
Description:
Recombinant protein was purified from E. coli lysate. After ammonium sulfate precipitation and subsequent steps, the supernatant (S100) was used for 5-LO activity assay.
Residue:
674
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50059714
Synonyms:
4-Furan-3-yl-7-[5-(4-hydroxy-tetrahydro-pyran-4-yl)-pyridin-3-ylmethoxy]-naphthalene-2-carbonitrile | CHEMBL316641
Type:
Small organic molecule
Emp. Form.:
C26H22N2O4
Mol. Mass.:
426.4639
SMILES:
OC1(CCOCC1)c1cncc(COc2ccc3c(cc(cc3c2)C#N)-c2ccoc2)c1
Structure:
Search PDB for entries with ligand similarity: