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Target
Translocator protein
Ligand
BDBM50060108
Substrate
n/a
Meas. Tech.
ChEMBL_39448 (CHEMBL653024)
IC50
>10±n/a nM
Citation
 Trapani, G; Franco, M; Ricciardi, L; Latrofa, A; Genchi, G; Sanna, E; Tuveri, F; Cagetti, E; Biggio, G; Liso, G Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type. J Med Chem 40:3109-18 (1997) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50060108
Synonyms:
CHEMBL104007 | [6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetic acid 1-ethyl-propyl ester
Type:
Small organic molecule
Emp. Form.:
C20H20Cl2N2O2
Mol. Mass.:
391.291
SMILES:
CCC(CC)OC(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Structure:
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