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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50061952
Substrate
n/a
Meas. Tech.
ChEMBL_62488 (CHEMBL677380)
Ki
4830±n/a nM
Citation
 Lomenzo, SA; Izenwasser, S; Katz, JL; Terry, PD; Zhu, N; Klein, CL; Trudell, ML Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives. J Med Chem 40:4406-14 (1998) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50061952
Synonyms:
(3,6-Dibenzyl-8-methyl-8-aza-bicyclo[3.2.1]oct-2-en-2-yl)-acetic acid methyl ester; hydrochloride | CHEMBL542492
Type:
Small organic molecule
Emp. Form.:
C25H29NO2
Mol. Mass.:
375.5033
SMILES:
COC(=O)CC1=C(Cc2ccccc2)CC2C(Cc3ccccc3)CC1N2C |c:5,TLB:17:16:26:5.6.14,THB:4:5:26:16.24,7:6:26:16.24,27:26:5.6.14:16.24|
Structure:
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