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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50061998
Substrate
n/a
Meas. Tech.
ChEMBL_48268 (CHEMBL663173)
IC50
46±n/a nM
Citation
 Trivedi, BK; Padia, JK; Holmes, A; Rose, S; Wright, DS; Hinton, JP; Pritchard, MC; Eden, JM; Kneen, C; Webdale, L; Suman-Chauhan, N; Boden, P; Singh, L; Field, MJ; Hill, D Second generation"peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile. J Med Chem 41:38-45 (1998) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49196.59
Organism:
MOUSE
Description:
Cholecystokinin A CCKBR MOUSE::P56481
Residue:
453
Sequence:
MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50061998
Synonyms:
CHEMBL140073 | [(R)-1-Cycloheptylcarbamoyl-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester
Type:
Small organic molecule
Emp. Form.:
C30H41N3O3
Mol. Mass.:
491.6648
SMILES:
C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCCC1 |wU:1.13,wD:1.0,TLB:18:19:16.17.22:23,15:16:23:19.25.20,THB:18:17:23:19.25.20,20:21:16:19.18.25,20:19:16:21.22.23,(1.12,-6.8,;1.13,-8.18,;1.22,-9.73,;2.58,-10.43,;1.34,-11.35,;1.81,-12.81,;3.36,-12.8,;4.39,-13.95,;5.89,-13.63,;6.37,-12.17,;5.34,-11.02,;3.85,-11.35,;-.25,-7.67,;-1.54,-8.51,;-1.51,-9.99,;-2.93,-7.83,;-4.22,-8.68,;-5.61,-8.09,;-6.97,-8.58,;-6.96,-10.07,;-8.17,-11.35,;-6.65,-10.92,;-6.67,-9.33,;-5.25,-11.5,;-4.23,-10.22,;-5.64,-10.57,;2.42,-7.5,;2.4,-6.12,;3.66,-8.23,;5.01,-7.46,;6.29,-8.32,;7.76,-7.86,;8.32,-6.43,;7.54,-5.09,;6.02,-4.87,;4.9,-5.93,)|
Structure:
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