Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50067044
Substrate
n/a
Meas. Tech.
ChEMBL_90571 (CHEMBL702428)
IC50
>100000±n/a nM
Citation
Artico, M; Di Santo, R; Costi, R; Novellino, E; Greco, G; Massa, S; Tramontano, E; Marongiu, ME; De Montis, A; La Colla, P Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling. J Med Chem 41:3948-60 (1998) [PubMed] Article
More Info.:
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
Inhibitor
Name:
BDBM50067044
Synonyms:
(1E,4E)-1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-3-one | (1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one | 1,5-Bis(4-hydroxyphenyl)penta-1,4-dien-3-one | 1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-3-one | CHEMBL129134
Type:
Small organic molecule
Emp. Form.:
C17H14O3
Mol. Mass.:
266.2913
SMILES:
Oc1ccc(\C=C\C(=O)\C=C\c2ccc(O)cc2)cc1