Reaction Details Report a problem with these data
Target
B2 bradykinin receptor
Ligand
BDBM50067917
Substrate
n/a
Meas. Tech.
ChEMBL_40274 (CHEMBL656509)
IC50
0.58±n/a nM
Citation
 Abe, Y; Kayakiri, H; Satoh, S; Inoue, T; Sawada, Y; Inamura, N; Asano, M; Aramori, I; Hatori, C; Sawai, H; Oku, T; Tanaka, H A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 4. Discovery of novel frameworks mimicking the active conformation. J Med Chem 41:4587-98 (1998) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKRB2_CAVPO | Bradykinin B2 receptor
Type:
n/a
Mol. Mass.:
42217.03
Organism:
Cavia porcellus
Description:
n/a
Residue:
372
Sequence:
MFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGHNVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWARSSSEGTPPGLL
  
Inhibitor
Name:
BDBM50067917
Synonyms:
(E)-N-{1-[3-(2-Methyl-quinolin-8-yloxymethyl)-2,4-bis-(2-oxo-pyrrolidin-1-yl)-phenyl]-1H-pyrrol-2-ylmethyl}-3-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-acrylamide; hydrochloride | CHEMBL553315
Type:
Small organic molecule
Emp. Form.:
C43H42N6O5
Mol. Mass.:
722.8308
SMILES:
Cc1ccc2cccc(OCc3c(ccc(c3N3CCCC3=O)-n3cccc3CNC(=O)\C=C\c3ccc(cc3)N3CCCC3=O)N3CCCC3=O)c2n1
Structure:
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